Bone health
Vitamin K — a healthy little secret that’s good from heart to bone
by Dr. Susan Brown, PhD
How often have you heard about vitamin K in the news or at your doctor’s office?
My guess is not much. Many people used to say vitamin K wasn’t even a “real” vitamin,
and that it simply helped us clot blood. But we’ve since learned a lot about its
amazing benefits to the body, and it looks to me like we should start paying attention
to this little known vitamin.
As it turns out, vitamin K plays an integral role not just in blood clotting, but
— importantly for women — for bone health and heart health. Most of us have enough
vitamin K to provide for normal blood coagulation, but you may need more to protect
your bones and cardiovascular health. Studies suggest that women would do well with
a daily K1 intake of about 1000 micrograms, yet the average intake in this country
is only one-tenth that amount!
Did you know?
- Discovered in the 1930’s by a Danish biochemist, the “K” in vitamin K stands for
koagulere, meaning “to coagulate” or “to clot.”
- In a review of over 4800 people known as the Rotterdam study, those who consumed
the most vitamin K2 had a 50% reduced risk of arterial calcification. They also
exhibited a 50% reduced risk for cardiovascular events during this 10-year period.
- In 2009, a 16,000-person study showed that a high intake of natural vitamin K2 was
protective against cardiovascular disease. This study reported that for every 10
mcg of vitamin K2 consumed, the risk of coronary heart disease was reduced by 9%.
References
Even though calcium is the buzz word when talking about healthy bones, I’ve noticed
an increased trend towards arterial calcification — hardening of the arteries
— when high-dose calcium is taken without benefit of other
key bone nutrients like K. So what’s a woman to do? The answer can be found
in vitamin K. Let’s take a closer look at this often overlooked vitamin and explore
its natural food sources. You may be surprised by how much K can do for you.
Keeping calcium in bone, not arteries
Vitamin K, specifically the vitamin K2 form known as menaquinone (MK-7),
plays an important role in keeping calcium in your bones — and out of your arteries.
Acting through what’s known as a Gla protein called osteocalcin,
vitamin K allows calcium to bind the bone matrix while the body is building new
bone. A similar molecule known as matrix Gla protein is synthesized by
vascular smooth muscle cells. In contrast to osteocalcin, matrix Gla protein prevents
calcification of soft tissue, meaning it stops calcium from being deposited
in the walls of your blood vessels (arterial calcification) — a very good thing
for anyone worried about heart health.
Both of these Gla proteins are essential for proper calcium metabolism, and neither
can be fully activated without adequate vitamin K.
These beneficial effects were observed in the prestigious Framingham Heart Study,
where those with the highest vitamin K1 intake (250 mcg/day, compared to the recommended
daily intake of 90 mcg/day ) had a threefold reduction in hip fracture risk. But
even an intake of vitamin K1 below 250 mcg a day can be to your bones’ advantage.
It was found in the 72,327-person Nurses’ Health Study that all the women consuming
over 109 mcg vitamin K1 a day had a lower risk of hip fracture over a ten-year period
than those consuming less than that.
The many kinds of K
Vitamin K is not a single nutrient but a family of related compounds. The two main
kinds of K that occur naturally are K1, or phylloquinone, which is of plant
origin; and K2, or the menaquinones, which are primarily of microbial origin.
A third, manmade type includes K3 (menadione), K4, and K5.
- K1 is found in sea vegetables, many green vegetables, and some fruits (see food
chart below). It is the form that is primarily taken up and utilized first in the
liver, and needed most for stimulating blood coagulation. K1 represents about 90%
of the vitamin K consumed in a typical Western diet.
- K2, which makes up about 10% of the K intake in a typical Western diet, comes in
a number of subforms usually abbreviated as MK-4 through -10. Although K2 is transported
to and found in the liver, it is thought to be most bioactive in bone, cartilage,
and vascular tissues.
- MK-4 is the form of menaquinone synthesized by animals (including humans), and found
only in animal products. Its biological function is not yet fully understood.
- MK-7, MK-8, and MK-9 are produced by bacteria and are found in fermented food products
like ripe cheese and fermented beans (e.g., natto). In comparison to MK-4 supplements,
the form known as MK-7 remains in circulation far longer in the body.
- K3 is a synthetic form not recommended for use as a nutritional supplement.
References
The best vitamin K food sources
So how can you get enough vitamin K? Different kinds of foods contain different
kinds of vitamin K, but generally, dark green leafy vegetables and fermented foods
are the best sources.
For women, the current recommended daily intake (RDI) of vitamin K1
is 90 mcg, but as noted above, research suggests an intake of 1000 mcg/day could
be of tremendous benefit to the bones, the blood vessels, and whole-body health.
See the vitamin K table to learn which foods contain K1, and about how much you’re
getting in a half-cup serving.
Vitamin K2 is the most biologically active form in terms of bone
and vascular health maximization, specifically the form known as MK-7. Produced
by bacteria, MK-7 is found mainly in certain cultured foods such as ripe cheese
and, most notably, a fermented soybean dish known as natto. Having a characteristic
strong odor, natto is sometimes called the “Limburger cheese” of Japan. Natto is
by far the best food source for MK-7, but some people find it too strong for their
liking. Check the vitamin K table for some other ways to get your K2.
Like vitamins A, D, and E, vitamin K is a fat-soluble vitamin, so its absorption
from vegetable sources is enhanced by the presence of dietary fat in the same meal.
So go ahead and drizzle olive oil onto your steamed greens, or braise them in some
butter!
Food sources of vitamin K
|
Food
|
Approx. K1 content (mcg/½-cup)
|
|
Wakame seaweed, dried
|
1293
|
|
Kale, fresh, cooked
|
530
|
|
Collard greens, fresh, cooked
|
418
|
|
Spinach, fresh, cooked
|
445
|
|
Laver seaweed, dried
|
413
|
|
Turnip greens, fresh, cooked
|
265
|
|
Beet greens, fresh, cooked
|
348
|
|
Watercress, raw
|
315
|
|
Dandelion greens, cooked
|
288
|
|
Mustard greens, fresh, cooked
|
210
|
|
Hijiki seaweed, dried
|
175
|
|
Parsley, 10 sprigs
|
164
|
|
Broccoli, fresh, cooked
|
110
|
|
Brussels sprouts, fresh, cooked
|
109
|
|
Onions, spring or scallions, raw
|
103
|
|
Curry powder
|
93
|
|
Asparagus, frozen, cooked
|
72
|
|
Lettuce, green leaf, raw
|
35
|
|
Lettuce, Cos or romaine, raw
|
28
|
|
Sauerkraut
|
25
|
|
Soybeans, fresh, cooked
|
15
|
|
Lettuce, butterhead (Boston or Bibb), raw, 1 leaf
|
8
|
|
Lettuce, iceberg, raw
|
6
|
|
|
Food
|
Approx. K2 content (mcg/100 g —3.5 oz., or ½-cup)
|
|
MK-4
|
MK-7
|
|
Natto (fermented soybeans)
|
2
|
939
|
|
Goose liver paste
|
369
|
|
|
Hen’s eggs, yolk, raw
|
64
|
|
|
Chicken, thigh, raw
|
27
|
|
|
Butter
|
21
|
|
|
Mayonnaise, whole egg
|
17
|
|
|
Beef, chuck, raw
|
15
|
|
|
Cream
|
8
|
|
|
Hen’s eggs, whole, raw
|
7
|
|
|
Pork, thigh, raw
|
6
|
|
|
Curry powder
|
|
|
|
Processed cheese
|
5
|
0.3
|
|
Yogurt, whole milk, plain
|
1
|
0.1
|
|
References
Not a fan of greens or slippery beans?
Daily replenishment of vitamin K1 is important because reserves in your liver turn
over quite quickly. There is evidence that vitamin K2 is produced by friendly bacteria
in our lower intestines, but we don’t really know to what extent this K2 gets absorbed
and contributes to your body’s daily demands. What we can deduce is that if intestinal
bacteria were supplying us with all the K our bodies required, osteoporosis and
cardiovascular disease in women would not be so widespread today.
But unless you are a lover of seaweed, greens, or fermented beans, you might find
it difficult to consume enough vitamin K from food each day. Take heart and do the
best you can. If you suspect that your vitamin K intake is low, you can also use
vitamin supplements. Though it seems to run counter to everything we believe about
a whole foods diet, studies suggest that in the case of vitamin K, absorption from
a tablet is considerably higher and faster than it is from vegetables.
Check the tables above to see if your intake is high enough. If you fall short,
add foods high in vitamin K to your grocery list right now. If the health of your
bones and blood vessels are of concern to you, discuss vitamin K supplementation
with your health professional.
If you’re taking medications to thin the blood, such as Coumadin, don’t take supplements
containing any form of vitamin K without careful monitoring from your physician.
Also be sure you consult with your practitioner before suddenly increasing consumption
of K-rich foods. In recent research, evidence is emerging that K2 is the form that
provides maximal protection with the fewest side effects — but remember, if you’re
on blood thinners, you’ll still need regular monitoring in follow-up.
Nutrients in harmony
I use the synergistic connection between calcium and vitamin K as a potent reminder
that vitamins and minerals work best for our bodies when they are taken together.
Bone health is not just about calcium or vitamin D or any singular vitamin, but
about a good base of nutrients working together. For more information, read my article
on 20 key nutrients for bone health.
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Related to this article:
References & further
reading on the benefits of Vitamin K
Last Modified Date: 05/25/2011
Principal Author: Dr. Susan E. Brown, PhD