Hormone replacement therapy
How often should I use my estradiol gel product, and where should I apply it?
Q: I was recommended to use a topical gel form of estradiol, but I’m
not sure how often is too often to use it, or where I should apply it for the best
effects. Does it make a difference where I use it?
A: Topical estradiol products (gels, mists, creams) are typically applied
once or twice daily. The makers of Estrogel, Estrasorb, Divigel, Elestrin, and Evamist
all suggest applying the product on the arms. Estrogel can also be applied to the
The main reason these sites are recommended is because that is where they were used
during the product studies; it doesn’t mean they won’t work if applied
elsewhere, only that these sites are known to be effective, whereas others have
not been studied. Out of an abundance of caution, topical hormones should never
be applied to the breast or skin that is irritated, and most of these products are
not designed to be applied to the genitals.
Even if you’re too busy, please don’t forget to read the product insert.
Be sure to do this every time you refill your prescription, too — there may
be important new information there!
Related to this article:
References & further reading for FAQ’s about
Last Modified Date: 04/15/2011
Principal Author: Marcy Holmes, NP, Certified Menopause Clinician