Menopause & perimenopause
Soy for menopausal symptoms —
References and further reading
1 Marini, H., et al. 2007. Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: A randomized trial. Ann. Int. Med., 146 (12), 839–847. URL (full text PDF): http://www.annals.org/cgi/reprint/146/12/839.pdf (accessed 01.26.2008).
Ikeda, Y, et al. 2006. Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-based Osteoporosis (JPOS) Study. J. Nutr., 136 (5), 1323–1328. URL (full text): http://jn.nutrition.org/cgi/content/full/136/5/1323 (accessed 01.26.2008).
Newton, K., et al. 2006. Soy protein and bone mineral density in older men and women: A randomized trial. Maturitas, 55 (3), 270–277. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16730418 (accessed 01.26.2008).
Ye, Y., et al. 2006. Soy isoflavones attenuate bone loss in early postmenopausal Chinese women. A single-blind randomized, placebo-controlled study. Eur. J. Nutr., 45 (6), 327–334. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16763748 (accessed 01.26.2008).
Arjmandi, B., et al. 2005. One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women. Nutrition J., 4, 8. URL (full text): http://www.nutritionj.com/content/4/1/8 (accessed 01.26.2008).
Ho, S., et al. 2005. A prospective study of the effects of 1-year calcium-fortified soy milk supplementation on dietary calcium intake and bone health in Chinese adolescent girls aged 14–16. Osteoporosis Int’l, 16 (12), 1907–1916. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16133646 (accessed 01.27.2008).
Roudsari, A., et al. 2005. Assessment of soy phytoestrogens — effects on bone turnover indicators in menopausal women with osteopenia in Iran: A before and after clinical trial. Nutr. J., 4, 30. URL (full text): http://www.nutritionj.com/content/4/1/30 (accessed 01.27.2008).
Zhang, X., et al. 2005. Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Arch. Int. Med., 165 (16), 1890–1895. URL (full text): http://archinte.ama-assn.org/cgi/content/full/165/16/1890 (accessed 01.27.2008).
Messina, M., et al. 2004. Skeletal benefits of soy isoflavones: A review of the clinical trial and epidemiologic data. Curr. Opin. Clin. Nutr. Metab. Care, 7 (6), 649–658. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/15534433 (accessed 01.27.2008).
Websites:
Nutraingredients.com. 07/07/2006. More evidence that soy isoflavones boost bone health. URL: http://www.nutraingredients-usa.com/news/ng.asp?n=68980 (accessed 02.12.2007).
2 Howes, L., et al. 2007. Isoflavone therapy for menopausal flushes: A systematic review and meta-analysis. Maturitas, 55 (3), 203–211. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16675169 (accessed 01.27.2008).
Daniells, S. 15/01/2007. Meta-analysis supports isoflavones for hot flushes. Nutraingredients.com. URL: http://www.nutraingredients.com/news/ng.asp?n=73353 (accessed 02.25.2007).
D&#rsquo;Anna, R., et al. 2007. Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: A 1-year randomized, double-blind, placebo-controlled study. Menopause, 14 (4), 648–655. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/17251874 (accessed 01.27.2008).
Crisafulli, A., et al. 2004. Effects of genistein on hot flushes in early postmenopausal women: A randomized, double-blind, EPT- and placebo-controlled study. Menopause, 11 (4), 400–404. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/15243277 (accessed 01.27.2008).
Krebs, E., et al. Phytoestrogens for treatment of menopausal symptoms: A systematic review. Obstet. Gynecol., 104 (4), 824–836. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/15458907 (accessed 01.27.2008).
Petri Nahas, E., et al. 2004. Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy. Maturitas, 48 (4), 372–380. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/15283929 (accessed 01.27.2008).
Appling, S., et al. Impact of soy on menopausal symptoms. Southern Nursing Research Society (SNRS) 17th Annual Conference, February 2003, Orlando, FL.
Kurzer, M., et al. Soy isoflavones decrease hot-flash frequency: A meta-analysis of studies examining soy protein, soyfood, and soy isoflavones. Fifth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, Sept. 21–24, 2003. Orlando, FL.
Messina, M., & Hughes, C. 2003. Efficacy of soy foods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flash frequency. J. Med. Food, 6 (1), 1–11. URL (abstract): http://www.liebertonline.com/doi/abs/10.1089/109662003765184697?journalCode=jmf (accessed 01.27.2008).
Han, K., et al. 2002. Benefits of soy isoflavone therapeutic regimen on menopausal symptoms. Ob. Gyn., 99 (3), 389–394. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11864664 (accessed 01.27.2008).
Faure, E., et al. 2002. Effects of a standardized soy extract on hot flushes: A multicenter, double-blind, randomized, placebo-controlled study. Menopause, 9 (5), 329–334. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12218721 (accessed 01.27.2008).
Morelli, V., & Naquin, C. 2002. Alternative therapies for traditional disease states: Menopause. Am. Fam. Phys., 66 (1), 129–134. URL (full text): http://www.aafp.org/afp/20020701/129.html (accessed 01.27.2008).
Nagata, C., et al. 2001. Soy product intake and hot flashes in Japanese women: Results from a community-based prospective study. Am. J. Epidemiol., 153 (8), 790–793. URL (full text): http://aje.oxfordjournals.org/cgi/content/full/153/8/790 (accessed 01.27.2008).
Somekawa, Y., et al. 2001. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Ob. Gyn., 97 (1), 109–115. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11152918 (accessed 01.27.2008).
Nagata, C., et al. 2000. Serum concentrations of estradiol and dehydroepiandrosterone sulfate and soy product intake in relation to psychologic well-being in peri- and postmenopausal Japanese women. Metabolism, 49 (12), 1561–1564. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11145117 (accessed 01.27.2008).
Scambia, G., et al. Clinical effects of a standardized soy extract in postmenopausal women: A pilot study. Menopause, 7 (2), 105–111. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/10746892 (accessed 01.27.2008).
Albertazzi, P., et al. 1998. The effect of dietary soy supplementation on hot flushes. Ob. Gyn., 91 (1), 6–11. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/9464712 (accessed 01.27.2008).
Websites:
Menopause relief through soy products at RevivalSoy.com. URL: http://www.revivalsoy.com/physlabs/benefits/menopause/# (accessed 02.12.2007).
Toronto Daily News. 10/30/2006. Soy isoflavone found effective for menopause relief. http://www.torontodailynews.com/index.php/HealthNews/
2006102805Menopause (accessed 02.12.2007).
3 Bryant, M., et al. Role of phytoestrogens on menstrual cycle symptoms. Fifth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, Sept. 21–24, 2003. Orlando, FL.
Ishiwata, N., et al. Effects of soy isoflavones on premenstrual syndrome. Fifth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, Sept. 21–24, 2003. Orlando, FL.
4 Casini, M., et al. 2006. Psychological assessment of the effects of treatment with phytoestrogens on postmenopausal women: A randomized, double-blind, crossover, placebo-controlled study. Fertil. Steril., 85 (4), 972–978. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16580383 (accessed 01.27.2008).
Kritz–Silverstein, D., et al. 2003. Isoflavones and cognitive function in older women: The SOy and Postmenopausal Health In Aging (SOPHIA) Study. Menopause, 10 (3), 196–202. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12792289 (accessed 01.27.2008).
5 Hanson, L. 2006. Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women. Am. J. Clin. Nutr., 84 (4), 774–780. URL: (full text): http://www.ajcn.org/cgi/content/full/84/4/774 (accessed 01.27.2008).
Sacks, F., et al. 2006. Soy protein, isoflavones, and cardiovascular health. An American Heart Association Science Advisory for professionals from the Nutrition Committee. Circulation, 113 (7), 1034–1044. URL: (full text): http://circ.ahajournals.org/cgi/content/full/113/7/1034 (accessed 01.27.2008).
6 Verheus, M., et al. 2007. Plasma phytoestrogen and subsequent breast cancer risk. J. Clin. Onc., 25 (6), 648–655. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/17200150 (accessed 01.27.2008).
Lu, L., et al. 2000. Decreased ovarian hormones during a soya diet: Implications for breast cancer prevention. Cancer Res., 60 (15), 4112–4121. URL: (full text): http://cancerres.aacrjournals.org/cgi/content/full/60/15/4112 (accessed 01.27.2008).
7 Salvo, V., et al. 2006. Antiestrogenic glyceollins suppress human breast and ovarian carcinoma tumorigenesis. Clin. Cancer Res., 12, 7159–7164. URL: (full text): http://cancerres.aacrjournals.org/cgi/content/full/60/15/4112 (accessed 01.27.2008).
Daniells, S. 11/01/2007. Glyceollins from soybeans may stop breast cancer cell growth. Nutraingredients. URL: http://www.nutraingredients.com/news/ng.asp?n=73254 (accessed 02.12.2007).
8 Panagotopulos, S., & Welty, F. Arteriosclerosis, Thrombosis, and Vascular Biology Conference. San Francisco, May 6–8, 2004.
DeNoon, D. 05/07/2004. Soy plus exercise relieves hot flashes better: The more women exercise, the more soy helps hot flashes. WebMD Medical News. URL: http://www.webmd.com/content/article/86/99197.htm (accessed on 01.31.2007).
9 Weed, S. 2002. Phytoestrogens — friends or foes? Can plant hormones help women in menopause? Do they affect breast cancer? Weed Wanderings Newsletter. URL: http://www.susunweed.com/herbal_ezine/
Weed_letter_Feb-02.htm (accessed 01.31.2007).
10 Williamson–Hughes, P., et al. 2006. Isoflavone supplements containing predominantly genistein reduce hot flash symptoms: A critical review of published studies. Menopause, 13 (5), 831–839. URL: (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16932241 (accessed 01.27.2008).
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Soy for menopausal symptoms
Original Publication Date: 02/12/2007
Last Modified: 08/17/2009
Principal Author: Marcella Sweet