Bone health
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3 McCormick, R. 2007.
4 Chiodini, I., et al. 2008. Skeletal involvement in adult patients with
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11 Bae, Y–J., et al. 2008. Calcium and magnesium supplementation improves
mineral content of the spine and serum osteoprotegerin in ovariectomized and calcium
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13 Certain signaling pathways in the body play key roles in the pathogenesis
of inflammatory arthritis and other bone–erosive processes. Indeed, the erosion
of bone is a pathological hallmark of several chronic inflammatory diseases, including
rheumatoid arthritis (RA) and periodontitis.
In 1998, the work of Gough and other British rheumatology researchers
suggested that osteoclastic activation, rather than suppression of bone formation,
was the principal mechanism leading to secondary osteoporosis in patients with rheumatoid
arthritis. In seeking to identify the clinical measures and biochemical markers
most indicative of bone loss in their early RA patients, they found that while urinary
pyridinoline and deoxypyridinoline (a crosslink of type 1 collagen, as measured
by Aeron Life Cycles’ Dpd assay) were excellent markers of change in BMD, CRP (C-reactive
protein) was the best overall.
See:
Gough, A., et al. 1998. Osteoclastic activation is the principal mechanism
leading to secondary osteoporosis in rheumatoid arthritis. J. Rheumatol. 25
(7), 1282–1289. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/9676757
(accessed 06.02.208).
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Inflammation and your bones
Last Modified: 04/18/2011