DHEA and adrenal imbalance
by Marcelle Pick, OB/GYN NP
Two months ago, Lisa, a 28-year-old mom, came to see me. She was so worn out from
mothering two kids and working full-time she couldn’t get out of bed. Just
driving to our practice took everything she had. Her tests revealed severe
adrenal imbalance and, as so often occurs in these cases, very low levels
of an important hormone called DHEA.
DHEA is a natural steroid and precursor hormone produced by the adrenals. It’s
also available at health food stores and on-line as an over-the-counter supplement.
Manufacturers hype it as a magic cure-all for many things: muscle loss,
weight loss, osteoporosis, and
depression — even menopause.
Recently headlines have linked DHEA to athletes “doping” with steroids,
leading to a lot of confusion about DHEA, its role in the body, and how it should
be used. Now DHEA is being labeled everything from “fountain of youth drug”
to fraud — and the very real benefits of DHEA, particularly for women, are
getting lost in all the controversy.
The truth is that — for the women who need it — adrenal support with
DHEA supplementation can make a big difference. I’ve seen it help patients
get going again when they feel like they’ve hit rock bottom. But it’s
never as simple as just popping a pill. When used appropriately — in a therapeutic
setting under medical supervision — DHEA is a critical component to jumpstarting
Just ask Lisa. After two months of treatment that included lifestyle changes and
adrenal support with low daily doses of DHEA, she feels like herself again.
So let’s give you more information about DHEA and its role in hormonal balance.
Then you can talk to your healthcare professional and make the best choice for your
What is DHEA?
Dehydroepiandrosterone, or DHEA, is a steroid hormone synthesized from cholesterol
and secreted by the adrenal glands. The adrenals are walnut-sized organs located
right above your kidneys. The average adult makes about 25 mg of DHEA per day (some
more, some less) with dwindling production as we get older. Men at all ages have
more DHEA than women.
Natural DHEA production is at its highest in your twenties: by the time we reach
seventy we only make about 20% of the DHEA we had when we were young. A decline
in DHEA with the passage of time is clearly what nature intended — and as
far as we know, a healthy process. This is only one of the major reasons we don’t
recommend self-prescribing DHEA through over-the-counter products.
Another reason is that DHEA is a very powerful precursor to all of your major sex
hormones: estrogen, progesterone, and testosterone. (Its molecular structure is
closely related to testosterone). We call it the “mother hormone” —
the source that fuels the body’s metabolic pathway:
Besides DHEA, your adrenals also make the stress hormones cortisol and adrenaline.
Adrenal exhaustion from coping with chronic stress — from (among other things)
poor nutrition, yo-yo dieting, emotional turmoil, and job-related stress —
means your adrenals are bone-tired from pumping out cortisol and they simply can’t
manufacture enough DHEA to support a healthy hormonal balance. The end result? You
feel tapped out, overwhelmed and, often, depressed.
It’s likely that DHEA and adrenal function are related to neurotransmitter-release
rates, based on the mood elevation our patients report after just two weeks of adrenal
support. But more research is needed to isolate the individual effects of DHEA from
the hormones it gets metabolized into before we can know for sure what part it plays
in all of this.
One thing we do know is that adequate levels of DHEA are needed to ensure your body
can produce the hormones it needs when it needs them. In that balanced state your
mood is stable and you feel clear-headed, joyful and vigorous. DHEA is the best
“feel-good” hormone we know. And it works quickly and effectively when
taken with the right combination of support.
When DHEA levels are low, your body does not have enough working material for proper
endocrine function. This throws off your hormone production and you feel a general
sense of malaise, along with other symptoms of hormonal imbalance — how severe
depends on how many other demands are being made on your body at the same time.
There is a growing body of evidence that healthy levels of DHEA may help stave off
Alzheimer’s disease, cancer, osteoporosis, depression, heart disease and obesity,
but there is still no clearcut consensus. There may be some increased risks associated
with DHEA for women with a history of breast cancer — all the more reason
to take DHEA under medical supervision.
At our practice we use DHEA where we’ve seen reliable proof of efficacy —
in cases of adrenal imbalance.
DHEA and adrenal imbalance
Your lifestyle, diet and stress levels all contribute to the amount of DHEA your
body can produce in a given period. At our practice we look first and foremost at
adrenal function, using DHEA levels as one of several diagnostic tools.
Think of our exhausted mother, Lisa. Like her, your adrenals work tirelessly to
meet the demands placed on them until they are utterly tapped. Without adequate
support, they spiral downward into adrenal imbalance and eventually adrenal exhaustion.
Most of the women we see at our practice — and I mean 99% — have some
indication of adrenal imbalance, including symptoms of low DHEA levels, such as:
- Extreme fatigue
- Decrease in muscle mass
- Decrease in bone density
- Aching joints
- Loss of libido
- Lowered immunity
But simply adding more DHEA to the equation is not the answer — despite what
some of the popular products claim. DHEA alone can’t fix adrenal imbalance
(don’t believe any product that says it will!), but it can be an important
factor in a combination approach that includes hormonal and nutritional support,
lifestyle changes, and proper rest.
(For more information on adrenal function and adrenal exhaustion, see our article
on adrenal health.)
Remember that DHEA is just one stop along the metabolic pathway — it doesn’t
work in a vacuum. How it gets converted comes down to your individual biochemistry
— some women may use it to make more estrogen, others may make more testosterone.
Just throwing a pill into the mix without understanding the bigger picture is never
a wise choice. Because having too much DHEA, or converting DHEA into too much of
one hormone and not enough of another, can be as upsetting to your body as not having
A delicate hormonal balance
So, you can’t look to DHEA supplementation as a stand-alone solution. It just
doesn’t work that way. DHEA is one part of the whole concert of hormones at
work every moment in your body. Before you tinker with that balance it’s a
good idea to understand what is going on in your life on all levels — physiologically
After menopause or a hysterectomy, when your adrenals become the primary hormone
factory, we see women in whom the ratio of DHEA that is converted into testosterone
outweighs what’s converted into estrogen and progesterone. This can cause
bouts of increased irritability and unusual body hair growth, especially when DHEA
supplements are given without prior and follow-up testing of total and “free”
“Free” testosterone is the portion of the hormone that is biologically
active in your bloodstream. After menopause, a woman may have volatile levels of
free testosterone at work, which accounts for some of the annoying male-pattern
facial hair that’s common during the transition. Most doctors only test total
testosterone levels, not the combined amount. Adding DHEA to this scenario can tip
the scale drastically.
On the other hand, I’ve also seen patients who convert most of their DHEA
into estrogen. In this case, DHEA supplements create a different kind of estrogen-progesterone
imbalance with symptoms similar to PMS, including breast tenderness and mood swings.
(See our article on estrogen dominance.)
Even though we’ve been trained in our culture to expect a one-size-fits-all
drug cure for every health issue, ingesting a powerful hormone like DHEA can be
unpredictable — and in some cases, risky. That’s why we advise our patients
not to self-medicate.
The trouble with over-the-counter DHEA supplements
Nowadays you can buy DHEA over-the-counter as a matter of course in a confusing
variety of doses and combinations. Most of these DHEA products are geared toward
men, but I’m seeing more and more aimed at women.
The labels claim DHEA will help us lose
weight, rev up our libido,
lift depression, and
give us back the strength, immunity, and stamina we had when we were 20 —
the age at which our bodies naturally produced the most DHEA.
While on the surface this is appealing (who wouldn’t want to feel 20 again?),
it’s obviously not what nature intended. We also don’t know enough about
DHEA to be conducting such a large, unregulated public experiment. DHEA is a potent
steroid — that’s why it’s been in the headlines and why it should
be approached with due diligence.
Without a comprehensive medical test it’s impossible to know what your DHEA
levels are. Just because you’re getting older doesn’t automatically
mean you’re deficient. Remember, this is a natural substance — our bodies
can produce more or less of it depending on our nutrient support, metabolism, hormonal
balance, activity level and emotional state.
In fact, there are many studies that show you can improve your DHEA levels naturally
by maintaining a body mass index of 19-25, getting adequate rest and exposure to
sunlight, exercising regularly (including sexual activity), and fostering more “downtime”
in your life — but more on that in a moment.
Also remember that any time you buy a supplement at a health food store you have
no guarantee that what you are buying is the real deal. There are few regulations
in place to police the manufacturing process or the product itself. (This is one
reason we have our nutritional supplements
made specifically for us by a manufacturer who tests every single batch.)
Many of the DHEA supplements I see at my local store have very high dosages —
way too high for most women (often as much as 20 times what I start my patients
on!). While there’s no way to tell how much of that you might actually absorb,
I think it’s especially unwise to experiment with DHEA at these levels without
Furthermore, taking DHEA alone won’t do any good if your adrenals are exhausted.
There are too many other factors at work. You need to know the status of your adrenal
function and your other hormones before you can even begin to know what kind of
combination of support your body needs.
That being said, if you’ve been taking a DHEA enhanced product — don’t
worry! Just call your doctor or medical practitioner and ask to get your hormones
tested — then you will know how to proceed.
How we test for DHEA at our practice
Saliva adrenal profiles can also be used to look at DHEA along with cortisol levels.
If I suspect adrenal imbalance, hormonal imbalance or a DHEA irregularity in a patient,
I often order is an adrenal panel. Using blood tests, I check estradiol in the follicular
phase (usually days 3–9 of a menstrual cycle); progesterone in the luteal phase
(days 14–28); DHEA-S; and both free and total testosterone levels. I like to see
estrogen, progesterone, and DHEA in the upper quadrant of normal.
What many traditional medical practitioners consider normal is a little low in my
opinion. I think there are many women who fall just shy of the bell curve in either
direction, but still in the range of “normal” by current standards, who have legitimate
health problems. (When such women go to a conventional practitioner feeling awful
they are told there’s nothing wrong.)
But I don’t just go by the numbers. I always look at how a woman is feeling; what
demands she’s placing on her body — particularly her adrenals — and her emotional
state. Sometimes a woman can test normal by conventional standards and still need
a slight, temporary boost.
What if you need DHEA?
If tests indicate the need for DHEA supplementation, I start patients off with as
little as 1-5 mg, under the tongue, two times per day. It’s possible to slowly up
the dosage if further tests warrant it, but I find I rarely need to use more than
10–12 mg sublingual per day — a physiological dose. We do not suggest any woman
exceed 25 mg per day if capsule forms are used.
I use only pharmaceutical-grade DHEA compounded by a reputable pharmacy. That way
I can be confident that what I’m prescribing is actually what the patient will get.
The kind I use comes in liquid sublingual drops — I prefer them to tablets. If your
doctor is unaware of a reliable compounding pharmacy in your area, log in to the
International Academy of Compounding Pharmacists’ website
to access their referral service.
Once a patient is taking DHEA, I closely monitor how she is metabolizing the hormone
through regular tests and face-to-face check-ups. Many women don’t need to take
DHEA for an extended period of time — once our bodies return to balance and we make
lifestyle changes, we’re usually more than capable of making what we need.
Many of my patients in menopause who are taking bioidentical hormones also take
DHEA to promote a good overall balance and vice-versa. DHEA can be a great bridge
through menopause. Again, once balance has been restored and symptoms even out,
most women produce enough DHEA on their own.
Which brings me to the point I most want to make about DHEA — its connection to
The best way to make more DHEA: cultivate joy
As I said before, DHEA is just one small part of a much larger picture — one
that you can exert considerable influence over. Our bodies produce DHEA all the
time. And it’s possible to measurably boost your body’s own production
of DHEA naturally.
Some studies show that people with a positive outlook actually create a self-sustaining
cycle of DHEA production: they produce more DHEA, which may affect their levels
(the happy neurotransmitter; for more see our article on
anti-depressants), which in turn gives them a better outlook — which
ups DHEA and so on.
One proven way to boost levels of DHEA naturally is to find ways to cultivate joy
in your life. This can mean different things to different people but overall there
are some common threads when weaving this web of joy:
- Connection: Human beings are social creatures — we like companionship.
Connecting with family and friends in a healthy, loving way is one of the best joy-makers
around. Or think long and hard about what you like to do for pleasure and reach
out. Join a local class or group that shares your interest.
- Exercise: Moving your body, even through deep breathing and mild
stretching, reduces stress, oxygenates your cells, and boosts mood-elevating substances
in your bloodstream called endorphins. This process can actually change your body
chemistry for the better. Meditation is also useful in this way.
- Spirituality: The ability to entertain the idea of some sort of
larger power, be it natural or divine, is a powerful component of joy. Rituals of
worship and contemplation, from a walk in the woods to yoga to prayer, helps us
make space in our busy lives to focus on what is truly meaningful to us and who
we really are.
- Play: Is it a coincidence that our levels of DHEA decline as we
enter the grown-up world of work and responsibility? Who knows? It would be interesting
to find out. But one thing is certain: playtime shouldn’t be just for kids.
Sometimes I actually have to write out a prescription that reads PLAY so
a patient can have fun without guilt. You too have my medical permission: go out
and play. Kick up your heels — it’s good for your health!
I know none of this is easy to do in today’s non-stop world. Everything around
us pushes us to have more, do more, be more — is it any wonder our bodies
eventually throw up a huge stop sign? The best time to foster hormonal balance,
adequate DHEA levels, and healthy adrenals is before you hit that stop sign. So
give yourself a time-out and check-in. You may find, with a little help, your body
and mind are more than capable of taking care of themselves.
The evolving wheel
Feelings of health and well-being are never static. Like all things natural, they
depend on a kaleidoscope of moving parts — always changing, always unique.
DHEA is just one part of this evolving pattern, one you can influence to create
a better picture by changing your lifestyle and taking care of your adrenals (for
more on this, read our article on adrenal health).
As with all things concerning your body, your mind, and your health, I hope you’ll
learn as much as you can about yourself and find a medical practitioner you can
talk openly with. DHEA should never be taken casually or unsupervised, but its benefits
are real for the women who need it — as are the physiological benefits of
cultivating joy. I encourage you to embrace the possibilities inherent in both!
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References & further reading on adrenal
Last Modified Date: 04/15/2011
Principal Author: Marcelle Pick, OB/GYN NP